Peripheral neuropathy is nerve damage that affects your hands, feet, arms and legs. It can cause tingling, numbness, burning or pain. Some people also experience weakness or balance problems.

Myeloma itself can damage nerves. So can some of the drugs used to treat it — mainly bortezomib (Velcade) and thalidomide (Thalomid). Newer drugs like lenalidomide and pomalidomide carry a much lower risk.

This guide explains how peripheral neuropathy happens, what symptoms to watch for, and how to manage them day to day. It covers pain relief options, exercise, massage, safety around the home, and when to talk to your doctor.

Early detection is key. Reporting symptoms early means your doctor can adjust your treatment before lasting damage occurs. The guide includes a self-monitoring checklist you can fill in before each clinic visit.

It also features practical tips from other people living with myeloma who have managed neuropathy themselves.